Sequential Pd(0)-, Rh(I)-, and Ru(II)-catalyzed reactions in a nine-step synthesis of clinprost.

نویسندگان

  • Emma E Nagy
  • I F Dempsey Hyatt
  • Kristen E Gettys
  • Shawn T Yeazell
  • Stephen K Frempong
  • Mitchell P Croatt
چکیده

A step-economical synthesis of clinprost is reported that concludes with 3 different transition metal-catalyzed reactions: Pd-catalyzed decarboxylation with allylic rearrangement, Rh-catalyzed diene-ene [2+2+1] reaction, and Ru-catalyzed cross-metathesis reaction. The complexity bestowed to the molecule from these reactions converts a readily accessible ester to clinprost without using protecting groups in only 9 total steps.

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عنوان ژورنال:
  • Organic letters

دوره 15 3  شماره 

صفحات  -

تاریخ انتشار 2013